Interference with the Feed-back Control of Histidine Biosynthesis

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The Biosynthesis of Histidine

It was later shown (2) that the mutant C84 accumulates imidazoleglycerol’ in the growth medium, that mutant Cl41 accumulates imidazoleglycerol and imidazoleacetol,2 and that T1710 accumulates L-histidinol.3 It was also observed that none of these compounds will replace histidine in promoting the growth of these mutants or other mutants blocked earlier in the sequence. This suggested that these ...

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The mechanisms by which a cell can control its biosynthetic processes are important from the point of cellular economy, yet they are little understood. It is known that bacteria must have such control systems, since their biochemical processes are so well coordinated, as shown by failure of the cell to accumulate large amounts of metabolites in the medium (1). Several indications of control mec...

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Histidine biosynthesis.

Histidine (His) is one of the standard amino acids in proteins, and plays a critical role in plant growth and development. The chemical properties of the imidazole side group allow His to participate in acid-base catalysis, and in the co-ordination of metal ions. Despite the biological importance of this molecule, His biosynthesis has been somewhat neglected in plants, in stark contrast to micr...

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Improvement of multi-parameter-based feed-forward coagulant dosing control systems with feed-back functionalities.

Coagulant dosing control in drinking and wastewater treatment plants (WWTPs) is often limited to flow proportional concepts. The advanced multi-parameter-based dosing control systems have significantly reduced coagulant consumption and improved outlet qualities. Due to the long retention time in separation stages, these models are mostly based on feed-forward (FF) models. This paper demonstrate...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1961

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)64068-2